• The transcription factor CREB has

  2019-07-02

  

  The transcription factor CREB has been extensively studied for its role in hippocampus-dependent learning and memory (West et al., 2002, Lonze and Ginty, 2002). Previous research has demonstrated that the phosphorylation of CREB at Ser133, performed by the ERK1/2 signaling pathway, initiates a casca

• br Conflict of interest br Acknowledgments This work was

  2019-07-02

  

  Conflict of interest Acknowledgments This work was supported in part by grants from the , Spain (INCITE08PXIB203092PR). VGM was supported by a FPU pre-doctoral scholarship from the , Spain. MLR was supported in part by a crowdfunding campaign (PRECIPITA), coordinated by the Spanish Foundation

• If the effects described here

  2019-07-02

  

  If the effects described here are present in catalysis, their empirical confirmation poses many challenges. Cat state correlations are fragile outside an environment especially suited for their preservation. As present day observational techniques whether in vivo or in vitro were not designed bearin

• novel isoform identification Ten non FH ADH probands fulfill

  2019-07-01

  

  Ten non-FH ADH probands fulfilled the diagnostic criteria of hyperabsorbers. Table 2 shows the main lipid characteristics of these subjects and of 10 non-hyperabsorber probands used for comparison. There were differences between groups in body mass index, waist circumference and triglycerides. Other

• br Discussion We herein report a case of

  2019-07-01

  

  Discussion We herein report a case of inappropriate shock therapy that was caused by T-wave oversensing and that occurred when the patient had sinus tachycardia and was squatting. Several methods were considered to troubleshoot this problem. We decreased the sensitivity and increased the NID and

• HQNO We observed a downregulation of several thyroid related

  2019-07-01

  

  We observed a downregulation of several thyroid-related genes such as DUOX1, DUOX2, TG, and TSHR. This may appear counterintuitive given that dedifferentiation typically worsens patient outcomes. However, it is noteworthy that there was no difference in the HQNO of SLC5A5 (sodium-iodide symporter),

• Recently denosumab demonstrated a significant delay in the o

  2019-07-01

  

  Recently, denosumab demonstrated a significant delay in the onset of detectable bone lesions in men with castration resistant prostate cancer compared to placebo . This could indicate some kind of efficacy of the compound as anticancer agent and consequently an indirect confirmation of the role of R

• Pyrrolidinedithiocarbamate ammonium br Discussion The major

  2019-07-01

  

  Discussion The major finding in this case is that implantation of an active-fixation atrial pacing lead in the right atrial appendage caused right coronary artery perforation, resulting in life-threatening tamponade. Myocardial perforation with or without cardiac tamponade has been reported as a

• br Ya desde el siglo

  2019-07-01

  

  Ya desde el siglo xvi, Salinas parece aceptar las innovaciones de Ramos Pareja que avanzaban en el siglo xv sobre lo que sería el temperamento igual. La obra de Salinas, Siete libros sobre la música, de 1577, entabla una explícita afinidad con las teorías de su contemporáneo Zarlino, como éste ido

• br Discussion HIV testing and linkage to

  2019-07-01

  

  Discussion HIV testing and linkage to care are essential for fighting the HIV epidemic, and evidence-based methods for increasing coverage of testing and accelerating linkage to care are needed. We report that abbreviated counselling was as effective as full length counselling in reducing sexual

• De cualquier modo la fecha

  2019-07-01

  

  De cualquier modo, la fecha para votar la propuesta del cuatripartito latinoamericano fue programada para el 16 de mayo de 1949. Tras intensos días de discusión, donde se pudieron observar las claras diferencias existentes también entre los países de América Latina, el balance final fue de 26 votos

• CLL associated HLH was first

  2019-07-01

  

  CLL associated HLH was first documented in the form of a case series report which included six patients treated for CLL who subsequently developed the phagocytic syndrome months to years later.[7] As these cases occurred prior to publication of the 1991 HLH diagnostic guidelines, the authors postula

• Introduction Researchers have long followed

  2019-06-29

  

  Introduction Researchers have long followed the strategy that in order to achieve a fuller understanding of the causes of disease and how they can be prevented, it is necessary to study the biochemical and physiological processes involved in the etiology of disease. As I have argued in previous pap

• br Case report A years old man

  2019-06-29

  

  Case report A 51-years-old man visited our hospital presenting with a palpable mass over the right inguinal area which had persisted for 3 months. This lesion was approximately 3–4 cm, firm and had progressively enlarged. Laboratory data showed no remarkable anomaly except elevated lactate dehydr

• br Erythropoietin and the HSC niche Many

  2019-06-29

  

  Erythropoietin and the HSC niche Many molecules produced both locally and systemically, including erythropoietin (Epo) and adrenergic catecholamines, also appear to affect HSC niche and metastatic lesions in the bone marrow. EPO is a hematopoietic hormone produced predominantly in the kidneys in

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