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Social interaction is known to be the
2019-10-14
Social interaction is known to be the main source of stress in human beings (Dickerson and Kemeny, 2004, Tamashiro et al., 2005). An animal model of social stress should closely mimic real-life situations in human life (Neisewander et al., 2012); in this context, social defeat in an agonistic encoun
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Another novel finding of our study was that the
2019-10-14
Another novel finding of our study was that the global 5 hmC was down-regulated and was associated with a substantial reduction of TET expression in the PE placentas compared with the controls. The decreased global 5 hmC level was consistent with the increased global 5 mC level in the preeclamptic p
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The use of AACSB accreditation
2019-10-12
The use of AACSB accreditation as an indicator of expected performance on the CPA exam has been examined by prior studies (e.g. Barilla et al., 2008, Boone et al., 2006, Grant et al., 2002, Howell and Heshizer, 2006, Lindsay and Campbell, 2003, Marts et al., 1998). While these studies are based on d
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Secondary and primary studies have considered the decision
2019-10-12
Secondary and primary studies have considered the decision to select the provider and to select components after the component origin is chosen. Examples of secondary and primary studies outside our scope, but still related to decision-making are listed in Tables 1 and 2. The secondary and primary s
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br User knowledge representation Various representation
2019-10-12
User knowledge representation Various representation approaches of user interests and preferences are proposed. In this work, we advocate a multidimensional semantic approach based on Bouzghoub et al. meta-model (Bouzeghoub and Kostadinov, 2005), depicted in Fig. 6, to model the user profile. The
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Ligand independent activation of neuronal nuclear estrogen
2019-10-12
Ligand-independent activation of neuronal nuclear estrogen receptors may also continue to occur in absence of ovarian estrogens. AF-1 requires intracellular kinase cascade-dependent phosphorylation of specific residues in the A/B domain of nuclear estrogen receptors (Le Goff et al., 1994; Kato et al
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br Effects of culture conditions on
2019-10-12
Effects of culture conditions on drug-induced gene LB42708 in primary human hepatocytes Past progress in elucidating the optimal conditions for the long-term cultivation of rodent hepatocytes has helped define some of the key components in the matrix and medium environment that are most critical
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Mammalian cells have two distinct DNA repair pathways for
2019-10-12
Mammalian 54011 pathway have two distinct DNA repair pathways for DSBs, NHEJ and HR. Our data are consistent with the suggestion that the DNA–PK-mediated NHEJ pathway recognizes DSBs faster than the HR pathway and acts before the activation of the DNA damage S-phase checkpoint. The activation of NH
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In anticipation of an approach based
2019-10-12
In anticipation of an approach based on modification of the cyclohexylacetic Tenovin-1 subunit of 1 as a means of improving permeability, a set of analogs were prepared to map out the optimum display of the acidic functionality. Homologated acids 25 and 26 were found to be equipotent to 1, although
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Clarithromycin clinical br Conclusion Our objective is to
2019-10-12
Conclusion Our objective is to promote cell activity on biomaterials, especially for use in regenerative medicine, by grafting THPs containing collagen-binding sites onto inert substrates. We have previously reported a methodology to derivatize EDC/NHS crosslinked films with photoreactive THPs. T
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With regards to what might represent a
2019-10-11
With regards to what might represent a typical “baseline” ChE (or AChE) activity in Saccostrea sp., it pretomanid should be remembered that the observed enzyme responses were obtained in laboratory exposures, over a narrow experimental window (96h), with specimens collected over the course of a wee
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Over the last decade numerous studies have
2019-10-11
Over the last decade, numerous studies have evaluated the acute, short-term, and medium-term impact of pulmonary vasodilators on Fontan physiology.23., 24., 25., 26., 27., 28., 29., 30., 31. Although different Ellagic acid mass of medications have been evaluated, phosphodiesterase-5 (PDE-5) inhibit
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The use of the periplasmic fraction as starting material and
2019-10-11
The use of the periplasmic fraction as starting material and the presence of a unique purification step concurred in improving the purification yield to 25.3%, which is significantly higher than what obtained with the previous purification protocol (6.7%). In addition, the analysis of the kinetic co
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Another important consideration with respect to drug conditi
2019-10-11
Another important consideration with respect to drug conditioning suggested by the present findings is the observation of an attenuated salubrinal on the second extinction trial. Seemingly, if ERK measurements were made following a partial reduction in the conditioned response the ERK response woul
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Furthermore elastase might not be the only regulator of
2019-10-11
Furthermore, elastase might not be the only regulator of CBG on cleaved and uncleaved form. In a study by Nenke et al. [85] α1-AT deficient subjects, who lack this native neutrophil elastase inhibitor, paradoxically have higher levels of uncleaved CBG and lower levels of CBG* [85]. Gender differenc
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