• br Conclusions br Introduction Astrocytes contribute to phys

  2021-12-16

  

  Conclusions Introduction Astrocytes contribute to physiological TBCA function on many levels. They help maintain the physiological composition of the extracellular medium by, for instance, buffering potassium and uptake of neurotransmitters. They can also provide neurons with energy substrate

• Interestingly studies from Sahai and colleagues in cancer as

  2021-12-16

  

  Interestingly, studies from Sahai and colleagues in cancer-associated fibroblasts have revealed that YAP is required for the acquirement of a stiff ECM in the tumor microenvironment (Calvo et al., 2013). Subsequently, this stiffening of the matrix can activate YAP, thus creating a feed-forward loop.

• Many studies have reported on the association

  2021-12-16

  

  Many studies have reported on the association between GST gene polymorphisms and pulmonary disorders but with controversial results [7]. In the present study, on comparing results of GSTP1 gene polymorphism among the studied COPD patient groups, it was found that heterozygote mutation was significa

• Dormancy is a physiological state when viable seeds do not

  2021-12-16

  

  Dormancy is a physiological state when viable seeds do not germinate. Seed stratification, a commonly used technique, is used for dormancy removal and can be performed in moisture for an experimentally revealed time at warm or cold temperatures. All conditions depends on plant species (Dębska et al.

• As disclosed in our preceding paper medicinal

  2021-12-16

  

  As disclosed in our preceding paper, medicinal chemistry SAR optimization of an HTS hit led to the discovery of , a potent and selective GPR119 agonist. This scaffold differs significantly from the ‘classical’ GPR119 pharmacophore, exemplified by the examples and (). Notably, Protein A/G lacks an e

• br Several reports have shown

  2021-12-16

  

  Several reports have shown an anti-proliferative effect of type I IFNs on CD4+ T AMG-208 mg activated in vitro either upon anti-CD3 antibody treatment [28,29] or upon cognate antigen stimulation [29]. However, the in vivo setting is a lot more complex, since the final outcome is the net effect of

• TCS 359 It is essential to maintain

  2021-12-16

  

  It is essential to maintain genome integrity and stability which is assaulted by oxidative stress. To perform this function, all human cells have well developed repair systems. Base excision repair (BER) system is the most effective pathway responsible to revert back lesions caused by oxidative stre

• The novel Ghsr IRES Cre knock

  2021-12-16

  

  The novel Ghsr-IRES-Cre knock-in mouse line allowed us to deconstruct the involvement of MBH GHSR-expressing neurons in mediating food intake responses using chemogenetic modulation of their neuronal activity. In our studies, hM4Di DREADD virus injections to inhibit GHSR neurons targeted several nuc

• Pentamidine br Materials and methods br

  2021-12-16

  

  Materials and methods Results Discussion Our data show that the ghrelin receptor, Ghsr, links energy homeostasis with a form of adult hippocampal plasticity. The presence of Ghsr on mature DG neurons suggest that acyl-ghrelin may modulate NSPCs indirectly, possibly via soluble factors such

• br Materials and methods br Results To examine the time

  2021-12-15

  

  Materials and methods Results To examine the time and organ specific effect of normal photoperiod and dark environment on the A-1210477 of different SlHXKs and on the enzyme activities, these parameters were determined in different leaf positions of tomato plants. Under control conditions, tr

• GPR levels were not changed by any treatment GPR

  2021-12-15

  

  GPR40 levels were not changed by any treatment. GPR40 has the same agonists as GPR120 but only a 10% homology [35] despite using the same intracellular signaling cascades [7]. Previous data on the ability of exercise to modulate G protein coupled receptors in general are scarce. The long-chain fatty

• Among the compounds prepared at this stage

  2021-12-15

  

  Among the compounds prepared at this stage, the cyclopropylmethylenoxy analogue attracted our most attention since it demonstrated particularly good in vitro potency at GlyT1 (16nM), no activity at the GlyT2 isoform up to the highest concentration tested (30μM), good physical properties with moderat

• In parallel we were also preparing and evaluating

  2021-12-15

  

  In parallel, we were also preparing and evaluating other piperidine bioisosteres and modifications to – to further access additional novel intellectual property (IP) space. Modeling work suggested that 4-position homologated piperidines, as well as 3-position homologated azetidines overlapped favora

• Petrat et al could show that even a low dosage

  2021-12-15

  

  Petrat et al. could show, that even a low dosage of 10-mg/kg glycine (133 μmol/kg) has a beneficial effect on the small intestine after I/R. In regard to glycine, β-alanine has a clearly higher EC50 to the GlyR and activates the receptor with an efficiency of only 34.6%.16, 17 Therefore, it can be c

• br Introduction The alternative splicing of

  2021-12-15

  

  Introduction The alternative splicing of pre-mRNA is essential for generating multiple matured mRNAs from a single gene by selectively removing introns. Neural saha inhibitor show many examples of regulated alternative splicing events, which produce structural changes in proteins important for th

15284 records 500/1019 page Previous Next First page 上5页 496497498499500 下5页 Last page