• To date the modes of actions of

  2024-06-03

  

  To date, the modes of actions of pharmaceuticals in humans and mammals are well-known (Fent et al., 2006), whereas knowledge of aquatic organisms, particularly invertebrates, is limited. This is problematic as these contaminants/pollutants have potentially harmful effects on wildlife organisms that

• Numerous studies have reported high

  2024-06-03

  

  Numerous studies have reported high glutamate levels in the brains of patients with depression, indicating that the glutamate system plays a crucial role in depression (Sanacora et al., 2004; Kendell et al., 2005; Hashimoto et al., 2007). Furthermore, several clinically effective antidepressant drug

• br Introduction S http www apexbt com

  2024-06-03

  

  Introduction Systemic lupus erythematosus (SLE) is a group of systemic autoimmune disorders characterized by anti-nuclear ABT-869 (ANA), rashes and photosensitivity, joint inflammation, nephritis, and other clinical criteria. SLE develops through the breakdown of three major checkpoints: adaptive

• Autophagy is finalized through the coordinated

  2024-06-03

  

  Autophagy is finalized through the coordinated positioning and fusion of autophagosomes with lysosomes, during which an array of common and specific membrane traffic-associated proteins is mobilized. Among these proteins, small GTPases, like Rab7, Rab34, or Arl8, and their 340 7 proteins, regulate

• Pyrimidine is the important pharmacology core in many Aurora

  2024-06-03

  

  Pyrimidine is the important pharmacology core in many Aurora inhibitors, such as VX-680, ENMD-2076, CYC-116 and ENMD-2076 [12]. To identify additional effective Aurora inhibitors, we designed a series of 2,4-diaminopyrimidine compounds, our modeling studies suggested that the 20 hydroxyecdysone rece

• The combination of Aurora kinase inhibitors with standard

  2024-06-03

  

  The combination of Aurora kinase inhibitors with standard chemotherapeutics or radiotherapeutics are currently in progress, such as AZD1152 plus radiotherapy in various solid cancer models. In addition, Azzariti et al. found that AZD1152-HQPA enhanced oxaliplatin and gemcitabine effectiveness in the

• Aromatization of the pyrrole ring after anion capturing

  2024-06-03

  

  Aromatization of the pyrrole ring after anion capturing, using acceptor atoms with electron deficiency (B & Be), and substitution of strong electron withdrawing groups such as CN were three strategies used to design a new class of anion receptors. Comparison of the anion affinities of these anion re

• Two critical determinants of receptor

  2024-06-03

  

  Two critical determinants of receptor trafficking are found within the GABAB1 cytoplasmic tail: the di-leucine internalization signal (EKSRLL) (Margeta-Mitrovic et al., 2000, Restituito et al., 2005) and the ER retention signal (RSRR) (Calver et al., 2001, Margeta-Mitrovic et al., 2000, Pagano et al

• CORT induced hippocampal damage has been implicated in depre

  2024-06-03

  

  CORT-induced hippocampal damage has been implicated in depression, aging and long-term glucocorticoid therapy. Therefore, finding a drug that can protect hippocampal neurons from the adverse effects of CORT could have significant clinical benefits. In this regard, we tested the potential protective

• While we chose to divide our

  2024-05-31

  

  While we chose to divide our etiologies into three categories, it should be noted that such division has certain limitations. Even though URIs and the common cold are considered mainly viral in origin and rhinosinusitis mainly bacterial in origin,26, 27 there is considerable overlap between these co

• Introduction It has long been recognized that angiogenesis

  2024-05-31

  

  Introduction It has long been recognized that angiogenesis is critical to the growth, progression, and metastasis of many solid tumor types [1], and thus, drugs targeting the angiogenic pathway have been a topic of clinical investigation in the oncology community for many years. Angiogenesis is reg

• pacap It has been reported that

  2024-05-31

  

  It has been reported that trehalose shows beneficial effects in a mouse model of several neurodegenerative diseases [21], [22], [23]. There are also reports showing that trehalose can improve the impaired cognitive and learning ability and reduced Aβ deposit in hippocampus of APP/PS1 transgenic mice

• br Introduction There are greater than five million American

  2024-05-31

  

  Introduction There are greater than five million Americans living with Alzheimer's dementia and more than 35 million people worldwide [1], and without a way to stop or slow the progression, there will be nearly a tripling of individuals affected by 2050 (13.8 million) [1]. The urgency to develop

• In summary we identified a novel

  2024-05-31

  

  In summary, we identified a novel MLPH-ALK fusion in AST with discordant results of ALK IHC. In order not to overlook ALK-rearranged AST with rare fusion partners on IHC screening, a sensitive IHC method is preferable. Introduction Lung cancer remains the leading cause of cancer related deaths w

• tak 242 A straightforward synthetic pathway was

  2024-05-31

  

  A straightforward synthetic pathway was adopted to synthesize the target compounds as outlined in . The starting chloromethylquinazolinones (–) were synthesized from anthranilic tak 242 in two steps following reported procedures., , , The first step involves chloroacetylation of anthranilic acid u

15284 records 135/1019 page Previous Next First page 上5页 131132133134135 下5页 Last page